25 - hydroxy cholesterol synthesis
基本信息
| 申请号 | JP2017505254 | 申请日 | - |
| 公开（公告）号 | JP2017523198A | 公开（公告）日 | 2017-08-17 |
| 申请公布号 | JP2017523198A | 申请公布日 | 2017-08-17 |
| 分类号 | C07J9/00 | 分类 | 有机化学〔2〕; |
| 发明人 | - | 申请（专利权）人 | 杭州下沙生物科技有限公司 |
| 代理机构 | 橋本 | 代理人 | 浙江工▲業▼大学;浙江花園生物高科股▲ふん▼有限公司;杭州下沙生物科技有限公司 |
| 地址 | - | ||
| 法律状态 | - | ||
摘要
| 摘要 | The present invention discloses a method for synthesizing 25-hydroxy cholesterol. The method is as below: subjecting 24-dehydrocholesterol derivative as a raw material, which undergoes an addition reaction with a hydroxyl containing reagent in an organic solvent under catalysis, and then hydrolyzing the reaction product and separating to obtain 25-hydroxy cholesterol. The present invention adopts hydroxyl containing reagents such as water, formic acid, acetic acid, propionic acid, butyric acid, benzoic acid, p-methyl benzoic acid to replace the commonly used extremely toxic reagents such as Cr reagent, Hg reagent and polyfluorinated acetone in the prior art. The raw materials of the present invention are easily available, and have low effect on environment. The operation and post treatment are convenient. Moreover, the method has the advantages of mild reaction conditions, simple operation, good selectivity, high efficiency, high yield, simple post treatment, easy product separation, less three wastes and easy industrialization. |
