Cyclic compound having Anti-tumor activity and use thereof
基本信息
| 申请号 | WOCN2021100967 | 申请日 | - |
| 公开（公告）号 | WO2021254493A1 | 公开（公告）日 | 2021-12-23 |
| 申请公布号 | WO2021254493A1 | 申请公布日 | 2021-12-23 |
| 分类号 | C07D401/14;C07D405/14;C07D217/02;C07D401/12;C07D405/12;C07D413/12;C07D417/12;A61K31/502;A61P35/00 | 分类 | 有机化学〔2〕; |
| 发明人 | 李磐;党群;付小旦;马建斌;尹洲;蔡欣 | 申请（专利权）人 | 上海翊石医药科技有限公司 |
| 代理机构 | - | 代理人 | - |
| 地址 | - | ||
| 法律状态 | - | ||
摘要
| 摘要 | Provided are a compound that has a novel structure and acts as a PRMT5 inhibitor, a method for preparing a compound therefor, and a use thereof in treating a disease mediated by an PRMT5 inhibitor. Through experiments, such compounds showed strong inhibitory effects on a PRMT5 enzyme. Also provided is a method for synthesizing a compound, which features simple processing, is convenient to operate, and is beneficial for large-scale industrial production and application. |
